James S. Manuso, Ph.D., MBA is a biotechnology/pharmaceutical industry CEO and serial entrepreneur experienced in the foundation, management, financing, governance and sale of start-up, public, private, domestic and international companies with marketed and R&D-stage products. He has extensive investment banking, M&A, general management, and business, financial, corporate, and drug development expertise. Dr. Manuso has served as board chairman, and chairman of audit, governance and nominating, pricing and compensation committees of multiple companies’ boards. He has executed financings, M&A transactions and other deals for biotech and pharmaceutical companies in excess of $2 billion dollars and is considered a “financial expert” under Sarbanes-Oxley regulations.
Dr. Manuso is Chairman and CEO of two companies -- Talfinium Investments, Inc., an investment entity, and Laurelside LLC, a family office. He serves on the board of Ocuphire, a Nasdaq-listed company (OCUP) developing Nyxol in advanced clinical trials for the treatment of multiple visual disorders. Dr. Manuso served as chairman and chief executive officer of Astex Pharmaceuticals, Inc. (NASDAQ:ASTX), formerly SuperGen (NASDAQ:SUPG), from July 2011 until October, 2013, at which time he engineered a sale of the company to Otsuka Pharmaceuticals for $886MM. In 2011, Dr. Manuso spun out Astex technology that enabled the foundation and financing of Tolero Pharmaceuticals, sold to Sumitomo for up to $780MM in 2017. Previously, from January 2004 to July 2011, he served as chairman, president and CEO of SuperGen, a commercial-stage company, and as a director since February 2001. Dr. Manuso is co-founder and immediate past president and chief executive officer of Galenica Pharmaceuticals, Inc. He co-founded and served as Vice Chairman & EVP of Business Development for Symbiontics, Inc., (sold to BioMarin as ZyStor, Inc. for $110 Million). He co-founded and was general partner of PrimeTech Partners, a biotechnology venture management partnership, from 1998 to 2002, and Managing General Partner of The Channel Group LLC, an international life sciences corporate advisory firm which he co-founded.